What's new in Discngine Assay?

Discngine Assay 6.4.1 | May 2024 

New features 

Close a job after the worklist creation 

• You can now generate a worklist for robotic equipment without having to load the associated log file in the same job. 

• You can choose to close the job directly without any log file, to use the copy of the worklist generator, or to upload the file returned by the robotic equipment. 

Upgrade Spotfire® Compatibility to version 14 LTS 

• Assay is now compatible with TIBCO Spotfire® 14.0 LTS. This is the only version supported by the application. 

Improvements 

• Filling layout have the index in the display well 

• Multiple files upload when doing the registration 

• Improvement of the plate viewer at the registration 

• Define the file extension when creating a worklist 

• Improve storage locations visualization 

• Use external barcode by default instead of the ones generated by Sample 

• Change the way the selection of the visualization tool (PP, Spotfire) is working 

• Add a previous and a home button on visualization pages 

Discngine Assay 6.4.0 | April 2024 

Improvements 

• Move plate layout in RefData 

• Upgrade Apex to version 23.2 

• Add and run oml cutoffs 

• See annotations in the Spotfire® visualisations 

• Make PP readers compatible with multiple reader 

Discngine Assay 6.3.0 | December 2023 

New Features

Dispense a volume from vial(s) 

• A new dispensing vial workflow is now available. It allows users to register a manual dispense in one or more vials. This workflow is reachable as the others from the "Create new job" page in the section Update. A quick access version of this workflow is also available from the Vial/Rack Search pages, and Vial/Rack Details pages, by using the Utilities panel on the right side of these pages. 

Include the Survey in the "Update Inventory from File" workflow 

• The "Update Inventory From file" is able to do a Survey. 

• A new robotic parser should be declared in the administration using the move type "SURVEY". 

"Update inventory from file" workflow can handle racks and vials 

• The "Update Inventory From file" is able to update the vials' position in racks. 

• A new robotic parser should be declared in the administration using the move type "VIAL". 

Invalidate wells for the "Update Inventory from File" workflow 

• The wells have a new status: valid or invalid. 

• By default, all wells are valid. For now, only robotic parsers can define when wells become invalid. 

• The validity of the wells is displayed on the plate detail page on the plate viewer. 

• The well validity is always transferred when doing a transformation (cherry-picking, compression, decompression, or replication). 

Control Layout in Sample 

• Control layouts (and well types) can be used in Sample. 

• Control layouts declared in the Assay module can be applied to any plates of the inventory: 

• multiple plates on the plates list page 

• individually on the plate detail page 

• when creating new plates during a workflow (including the reception) at the Storing (Ouput) step 

• The well types are automatically transferred from one plate to another when doing a transformation. 

Create a parser for the Echo 655 and 550 robotics equipment 

• Two new robotic parsers are available: Echo 655 and Echo 550. 

• The following columns are retrieved: 

• Source Plate Barcode 

• Source Well 

• Destination Plate Barcode 

• Destination Well 

• "Destination Plate Type" or "Destination Plate Name": needed to create the new plate 

• Actual Volume: volume to be transferred in the "Destination Well" (always nL) 

• Current Fluid Volume: used to update the source quantity when an exception is generated (always uL) 

• % DMSO: source wells are updated with these values and stored as metadata if the "% DMSO" is declared in RefData 

Registration improvements 

• The registration workflows can now be used with custom parsers in order to accomodate for file formats that cannot be read by the file mapper and streamline the registration process in Sample. 

Add referential to batch type 

• For each of the available batch types, you can add Oracle functions to retrieve data from a referential system. This enables you to control that the information of you batches comes from a reliable and centralized source. 

Add/modify annotations at Storing (output) step 

• You can now add annotations (metadata) from the Storing (output) step of your jobs. This option is only available as long as the job is open. Once the job is closed, the option is locked. 

Assay - Multiple Reader 

• The start of a run has been redesigned. 

• The already existing mode "Design from template" has been clearly defined. 

• The File reading page has been completely redesigned. 

• You can now use more than one reader in the entry of a run. 

• Old readers may need an upgrade to work with this feature. Reach the assay team if you want to upgrade it. 

Assay : Revamp the analysis steps with Spotfire without refreshing the page 

• In both Pipeline Pilot and Spotfire, the look and feel of the Well Validation, Reference Analysis, Sample Analysis, and cross runs pages have been improved 

• In Design mode, you can add normalizations and automatic analysis from a modal page. 

• With Spotfire, you are no longer redirected to the waiting page, the data is automatically refreshed when data is added or removed. 

• With Spotfire, you can validate/invalidate/revalidate any data without refreshing the page. You can continue your analysis during the calculation, your marked data will be kept. 

• With Spotfire, you can switch from another template to a modal accessible from the parameter at the top right of the page 

Assay : Add control vocabularies in the Well Validation, Reference Analysis, and Sample Analysis step 

• Annotations have been added in Assay. 

• Annotations are managed in the Reference Data application. You can now annotate wells, and plates aggregated, and validated data in Assay at the Well Validation, Sample, and Reference Analysis. 

• A User Guide on How to manage annotation in Reference Data and Assay has been created. 

OML4Py as a dng plugin for Assay 

• In this version, we have implemented a new possibility for running normalizations, reference analyses, and sample analyses: these can now be done using Python scripts. 

• As of 6.3, this is an internal possibility, which means that a deployment is required to make such a computation available. We are working on making this possibility available through the administration soon 

• Making good use of this functionality, we have implemented 3 normalizations that were previously only available through Pipeline Pilot 

• Normalized Percent Inhibition (NPI) 

• B-Score 

• Modified Gompertz 

Create multiply, substract, ratio and add Normalizations 

• Four new normalizations have been added, to replace, in the future, the readout transformations: 

• Readout Transformation - Add (Readout 1 + Readout 2) 

• Readout Transformation - Substract (Readout 1 - Readout 2) 

• Readout Transformation - Divide (Readout 1 / Readout 2) 

• Readout Transformation - Multiply (Readout 1 * Readout 2) 

Improvements 

• Update Pipeline Pilot to 2023 version + Test 

• Improve standard security with Pipeline Pilot for Assay 

• Update Spotfire to version 12 + Test 

• "Automatic Selection and Invalidation" has been renamed to "Automatic Analysis" 

• Better handle of readouts in a run 

Discngine Assay 6.2.2 | October 2023 

Improvements 

• The pED50 is now calculated using the "Dose-Response Fitting" calculation, in the Sample analysis step. 

Discngine Assay 6.2.1 | September 2023 

Improvements 

• The "Spectramax" reader has been improved as follows: 

• When there are multiple plate "blocks" in the same line, they should be considered as different readouts for the same plate. 

• When there are multiple plate "blocks" on the same column before the tag "End", they should be considered as the same readout but read multiple times. 

• Detection of the measurement performed with the corresponding parameters. 

Discngine Assay 6.2.0 | June 2023 

Read our blog article >

New Features 

• The administration of barcodes is available. You can now dispose and/or rename containers. This tool is available from the Sample Administration with the right of SAMPLE_ADMINISTRATOR. 

• A column for well position (row/column or well index) 

• A new reader called "Generic reader" has been created. It allows you to read a lot of tabulated TXT/CSV/XLSX formats by selecting a file mapping. To be able to read your file, this one needs to follow some information: 

• A column for plate identification (plate index and/or plate name) 

• A column for well position (row/column or well index) 

• A least one column of readouts 

Improvements 

• It is no longer necessary to enter the default value for solvents. 

• An administrator can define container metadata as free text or controlled vocabulary 

• The workflow "Container - Update attributes" has been updated accordingly to handle free text and controlled vocabulary 

• New APIs have been developed to retrieve the results 

Release notes DACA 6.1.1 | 2023 

Improvements 

• When your connection is successful, and you don't have any role, you are redirected to a page telling you to contact your administration to have proper access. 

• The speed of the search bar has been improved 

Release Notes DACA 6.1.0  

New Features 

• User experience 

• The theme of the application has been completely updated 

• The User Experience has been improved 

• The user can use a "Dark Theme" in the application (only if using Discngine Themes) 

• The home page has been completely redesigned 

• A new workflow has been created: Plate Creation 

• It allows the users to create a plate in a graphic way 

• The search to bar has been updated 

Improvements 

• Tibco Spotfire® 11.4 can now be used in the application 

Release Notes DACA 5.4.0  | November 2023 

New Features 

• In our cloud, R scripts can now be used in Warehouse to perform consolidations 

Improvements 

• Allow filters when using Spotfire Webplayer as a data viewer 

• Improve the R scripts in the Sample Analysis to support more result data types